NEW ANTIVIRAL ANTIBIOTICS; XANTHOCILLIN X MONO- AND DIMETHYLETHER, AND METHOXY- XANTHOCILLIN X DIMETHYLETHER. I
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چکیده
منابع مشابه
New antiviral antibiotics; xanthocillin X mono- and dimethylether, and methoxy-xanthocillin X dimethylether. I. Isolation and characterization. (Studies on antiviral and antitumor antibiotics. V).
The production, isolation, chemical and physical characteristics and biological properties of the new antiviral antibiotics, xanthocillin X monoand dimethylether, and methoxy-xanthocillin X dimethylether are described. They were produced by two strains of Aspergillus sp. isolated from soil samples. The active principles were extracted from the mycelium, and isolated as yellowish crystals. They ...
متن کاملNew antiviral antibiotics; xanthocillin X mono- and dimethylether, and methoxy-xanthocillin X dimethylether. II. Biological aspects of antiviral activity. (Studies on antiviral and antitumor antibiotics. VI).
Effects of XME, XDE and XTE (xanthocillin X monoand dimethylether, and methoxy-xanthocillin X dimethylether) on multiplication of Newcastle disease virus (NDV) and on proliferation of chick embryo fibroblast cells (CEF) were examined. At low multiplicity, XME, XDE and XTE suppressed CPE at low concentrations. At high multiplicity, XME (10 mcg/ml) completely inhibited occurrence of CPE and synth...
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Xanthocillin X monomethyl ether, known as an antiviral antibiotic, was isolated as a potent inhibitor of Dichotomomyces cejpii. The compound inhibited prostaglandin synthesis from 14C-arachidonic acid in rabbit kidney microsomes by 50% at a concentration of 0.2 microM, while prostaglandin synthesis by microsomes of ram seminal vesicle was inhibited by 50% at 20 microM. The inhibition of xanthoc...
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Flavones possessing prenyl substituents occur quite frequently in nature, so do those with 2 ,2 -dimethylpyran ring system [1,2]. Many of such py ranoflavones exhibit interesting biological activi ties. A health food, designed to prevent diseases, consisted of extracts of M orbus bombycis or relat ed plants (containing morusin (1 ) and/or its hy drate) [3]. Isopongaflavone (2) otherwise kno...
متن کاملBU-4704, a new member of the xanthocillin class.
Aspergillus sp. No. FA2692, isolated from a bark of Quercus mongolica collected in Shiga-kogen, Nagano Prefecture, Japan, was found to produce a newantibacterial and antifungal compounddesignated as BU-4704. The structure of BU-4704 was determined to be l -(4-methoxyphenyl)-4-(4-hydroxysulfonyloxyphenyl)-2,3-diisocyano1 ,3-butadiene, the xanthocillin class of antibiotics1 ~3). This paper deals ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 1968
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.21.671